在CNP类似物赛道,Ascendis的TransCon-CNP率先实现了剂型升级。与Vosoritide不一样的设计是TransCon-CNP被一层保护分子包裹,降低了体内清除影响,延长作用时间,实现每周一次给药。非头对头临床数据显示,TransCon-CNP每年2.29厘米的增高表现也优于Vosoritide。
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As before, the negotiations are being mediated by Oman, which has maintained a policy of neutrality and assumed the role of mediator both within the Arabian peninsula and more broadly across the Middle East. The country lies in the centre of tensions between the US and Iran and is directly vulnerable to maritime instability and regional escalation.